Poly rc binding protein 4

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August undefined, 2024

WebPoly(rC)-binding protein 2 (PCBP2) is an RNA-binding protein that is characterized by its ability to interact with poly(C) with high affinity in a sequence-specific manner. PCBP2 … WebAug 5, 2016 · 4. Discussion. Poly(rC) binding protein 2 (PCBP2, also called hnRNP E2 or α-CP2) belongs to the hnRNP-E family of RNA binding proteins that interact with a sequence-specific motif having single-stranded poly(C) tracts. PCBP2 contains a characteristic triple repeat of heterogeneous nuclear ribonucleoprotein K homology (KH)-domain.

Interaction between poly-A binding protein PABPC4 and

WebNov 1, 2024 · Iron chaperones include the multi-functional poly(rC)-binding proteins 1–4 (PCBPs). • PCBP1/2 play roles in iron metabolism, with the roles of PCBP3/4 being less clear. • The PCBPs bind 3 iron atoms and form hetero/homo dimer complexes. • PCBPs have a subset of non-redundant functions in iron metabolism. WebThe poly(rC)-binding proteins are a subfamily of KH-domain-containing RNA-binding proteins that bind C-rich pyrimidine tracts and play pivotal roles in a broad spectrum of … fun summer activities to do with teens

Poly(rC) binding protein 2 (PCBP2) promotes the viability of …

WebHere we discuss recent and old results devoted to type I IRESes and provide evidence that Poly(rC) binding protein 2 (PCBP2), Glycyl-tRNA synthetase (GARS), and Cold Shock Domain Containing E1 (CSDE1, also known as UNR) are major regulators of type I IRES activity. WebFeb 26, 2024 · Poly(rC) binding protein 2 (PCBP2), a 39 kDa protein, is a member of the α-globin mRNP stability complex [7, 8]. As a generally known RNA-binding protein, PCBP2 possesses three K homology domains, which are the main RNA-recognition regions [9, 10]. WebDec 8, 2024 · Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Apr 2024] Other designations. poly(rC)-binding protein 4, … fun summer activities in michigan

Multilevel regulation and molecular mechanism of poly (rC)‐binding …

Suppression of Poly(rC)-Binding Protein 4 (PCBP4) reduced …

WebOct 16, 2008 · Europe PMC is an archive of life sciences journal literature. Recombinant hnRNP K-homology (KH) domains 1 and 3 of the poly(rC)-binding protein (PCBP) 2 were purified and assayed for interaction with coxsackievirus B3 RNA in electrophoretic mobility shift assays using in vitro transcribed RNAs which represent signal structures of the 5' … WebJul 1, 2024 · Poly(rC)-binding protein 2 (PCBP2) is a member of the poly-cytosine binding protein (PCBP) family, which has been shown to function as regulators in various diseases, including hepatitis C virus infection [2], degenerating neurons [3], acute spinal cord injury [4], and chronic obstructive pulmonary disease [5]. github build errorWebFind poly a binding protein and related products for scientific research at MilliporeSigma. US EN. Applications Products Services ... Synonym(s): Anti-LIP4, Anti-LYST-interacting protein, Anti-MCG10, Anti-RNA binding protein MCG10, Anti-poly(rC) binding protein 4. Compare Product No. Clonality Application Species Reactivity Citations ... github building access app

"WebThe cellular protein poly (rC)-binding protein (PCBP) was identified as a primary candidate for regulating such a mechanism. Among the four different isoforms of PCBP in … " - Poly rc binding protein 4

Poly rc binding protein 4

Advances in poly(rC)-binding protein 2: Structure, molecular …

WebPoly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.. This gene encodes a member of the KH domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular … WebPoly(rC)-Binding Protein 4 (PCBP4) is an RNA-binding protein (RBP). It plays an important role in stabilizing mRNA and translation7,8. The PCBP family consists of hnRNP K, PCBP1, …

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WebDec 8, 2024 · Orthologous to human PCBP4 (poly(rC) binding protein 4). [provided by Alliance of Genome Resources, Apr 2024] Other designations. poly(rC)-binding protein 4, alpha-CP4. GeneRIFs: Gene References Into Functions. the p53-PCBP4-ZFP871 axis represents a novel feedback loop in the p53 pathway. ... WebNov 4, 2024 · PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR. Embryos lacking the KH domain poly (C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2 (-/-) embryonic liver reveals accentuated ...

WebNov 1, 2024 · Iron chaperones include the multi-functional poly(rC)-binding proteins 1–4 (PCBPs). • PCBP1/2 play roles in iron metabolism, with the roles of PCBP3/4 being less … WebApr 9, 2008 · A 5′-terminal cloverleaf RNA structure interacts with poly(rC) binding proteins (PCBPs) to protect uncapped PV mRNA from 5′ exonuclease (K. E. Murray, A. W. Roberts, and D. J. Barton, RNA 7:1126-1141, 2001). In this study, we examined de novo polysome formation using HeLa cell-free translation-replication reactions.

WebJan 19, 2011 · Leffers et al. (1995) described the cloning and characterization of 2 cDNAs for poly (rC)-binding proteins, called PCBP1 ( 601209) and PCBP2 by them. The authors analyzed an EST database for sequences that were predicted to encode a protein with K-homologous (KH) domains. The 60- to 70-amino acid KH motifs are found in several … WebRationale: Proper development of the heart relies on a tightly regulated, yet diverse, pattern of gene expression that is governed by transcriptional, post-transcriptional, and translational processe

WebPCBP1. Poly (rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene. [5] This intronless gene is thought to have been generated by retrotransposition of a …

WebGene ID: 128047921, updated on 28-Feb-2024. Summary Other designations. poly(rC)-binding protein 2 fun summer birthday party ideasWebSep 22, 2024 · The first pair studied was the protein pair avidin and Biotin. Avidin is a protein typically found in the egg whites while Biotin is a B vitamin. The large protein avidin, can bind 4 of the small Biotin molecules with dissociation constant on the order 10 −8 s −1 of making it one of the strongest non-covalent bonds [19,20]. github builderWebSingle-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:7607214, PubMed:12414943). Major cellular poly(rC)-binding protein … github build numberWebinternal ribosomal entry site (IRES). A cellular protein, the poly(rC) binding protein (PCBP), has been reported to interact with the CL either alone or in combination with viral protein 3CD pro. The formation of the ternary complex is essential for RNA replication and, hence, viral proliferation. PCBP also interacts with stem-loop IV of the IRES, fun summer acrylic drinking glassesWebMay 1, 2024 · Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells. Although PCBP1 ... fun summer appetizer ideasWebNov 14, 2024 · Poly(rC)-binding proteins (PCBPs), a defined subfamily of RNA binding proteins, are characterized by their high affinity and sequence-specific interaction with … github buildrootWebOrthologous to several human genes including PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Apr 2024] pcbp2 poly(rC) binding protein 2 [ (zebrafish)] Gene ID: 321844, updated on 4-Nov-2024. Summary. Enables mRNA 3'-UTR binding activity. Predicted to be ... github build artifacts