The mapec trial
SpletCurrent evidence on the circadian-time-dependent effects of hypertension medications and their combinations in relation to findings of MAPEC and Hygia Chronotherapy Trial. The … Splet14. mar. 2024 · The MAPEC and Hygia trials do suggest a beneficial effect of nighttime administration of antihypertensives on clinical outcomes, but confirmation by other studies is needed before definitive recommendations can be made about nighttime dosing of antihypertensive medication. References
The mapec trial
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Splet20. jul. 2024 · Despite the excellent trial design and execution, some cardiovascular researchers have questioned the integrity of the trial and believe patients should continue to take their antihypertensives... SpletThe just completed MAPEC study is the first trial specifically designed to prospectively test the hypothesis that bedtime administration of ≥1 conventional medications exerts better …
Splet21. nov. 2024 · A+. 晚上和早餐服用常规降压药物的主要心血管事件指标没有差异。. 高血压是心血管疾病的关键危险因素。. 充分控制血压可降低主要心血管事件的风险，包括中风、缺血性心脏病和心血管死亡。. 在抗高血压治疗获益的临床试验中，常规都是早晨服药。. 当使 … Spletthe only trial to have evaluated a comparison of the timing of all antihypertensive agents currently in use, on 24-hour ABPM levels and conflicts with results of the MAPEC study⁽⁵⁾. …
SpletThe results of this study (the MAPEC trial) were striking.(Ref 6) Over a median 5.6 years follow-up, adverse cardiovascular events occurred in 187 of 1084 subjects taking BP medication in the morning but only 68 of 1072 subjects who took their BP medication at bedtime (relative risk 0.39, 95%CI [0.29-0.51], p < 0.001). ... Splet06. nov. 2015 · New-onset diabetes was not a pre-specified endpoint in the published trial design [].However, the authors note that the MAPEC trial was designed to investigate, as major outcomes, total cardiovascular events, major vascular events, new-onset diabetes and new-onset chronic kidney disease.
Splet20. jul. 2024 · the MAPEC trial, the Hygia Chronotherapy Trial incor-porated a large number of relevant and novel features . never before integrated into any previously reported .
Splet07. dec. 2015 · To the Editor: We read with interest the commentary by Dr Rutter [] on our two companion papers from the MAPEC (Monitorización Ambulatoria para Predicción de Eventos Cardiovasculares) study, describing, respectively, prognostic value of asleep BP determined by ambulatory BP monitoring (ABPM) [] and reduced risk of new-onset type 2 … support house slippers for womenSpletIn the MAPEC study (Monitorizacin Ambulatoria de la ó Presión arterial y Eventos Cardiovasculares),5 bedtime dos-ing of at least 1 blood pressure-lowering agent … support housingSpletContext. Although Systolic Hypertension in Europe 1 and Heart Outcomes Prevention Evaluation 2 studies suggested nightly dosing of antihypertensive medications might lead to better cardiovascular outcomes, the Ambulatory Blood Pressure Monitoring for Prediction of Cardiovascular trial (ABPM), 3 or Monitorización Ambulatoria para … support housing fundSpletirregularities in the reporting of MAPEC’s results and methods.12 13 The MAPEC trial registry, for instance, was attributed to at least eight other RCTs,14–21 making it appear to describe a general programme of research, and not the methods of a single RCT. Following this, in 2024, the same principal investigator published another support house slippersSpletThe MAPEC Study is a prospective trial registered at www.clinicaltrials.gov, with identifier code NCT00295542. The complete list of investigators has been published previously … support housing haltonSpletmeans MAPEC is at all levels an interventional, not observa-tional,clinicaltrial.Inaddition,thereisnoscientificprooftoDr Rutter’s suggestions that asleep BP elevation might be the re-sult of diabetes; in fact, the novel findings of our trial are just oppositeindicating,instead,thatelevatedasleepBPisaprecur-sor of diabetes. support housing barnetSplet20. jul. 2024 · ABSTRACT. The purpose of this communication is to describe the unique features of the investigative protocols of both MAPEC and Hygia Chronotherapy Trial and to discuss in detail the advantages, limitations, and potential implications of their findings, both for the diagnosis and management of true arterial hypertension that we propose … support hp 250 g8 notebook pc